Bob Saget was busy under contract hosting CBS' The Morning Program, so the role of Danny Tanner was played by John Posey. Jesse Katsopolis' original name was "Jesse Cochran." John Stamos wanted his character's name to reflect on his Greek culture, so his last name was later changed.
Some other notable differences include: Dave Coulier is credited as David Coulier, Richard Correll as the producer, the EP credits in the opening (and no creator credit), and the Jeff Franklin Productions and Miller-Boyett Productions logos in white (the former has "Productions" in a different font), and Michelle waving goodbye in front of the camera prior to the Lorimar Telepictures logo.
The closing theme song is also vocal, like the opening, which has the show's title all on one line.
The plot of the pilot is essentially the same as the premiere episode.